INDIANAPOLIS -- The Indianapolis Colts spent Wednesday adapting to the new reality that leading tackler DQwell Jackson will miss the last four games of the regular season.One day after the league suspended Jackson for violating the leagues performance-enhancing substance policy, inside linebackers Edwin Jackson and Antonio Morrison were getting acclimated to being the defenses new signal-callers. Others tried to fill the void of one of the Colts steadiest locker room leaders.Its an obvious letdown, tight end Dwayne Allen said. We want those guys on the field, but we also understand mistakes happen.Neither the league nor the Colts have said what substance Jackson used.Jackson wont be permitted back at the team complex until Jan. 2, when the Colts will either be cleaning out their lockers or preparing for a playoff game.The timing couldnt be worse.After losing their first two games, the Colts (6-6) have been fighting to get back into playoff position . Now, with three wins in four games, Indy has moved into a three-way tie atop the AFC South with Houston and Tennessee, and seemed to be building momentum for the key stretch run.Suddenly, the offense appeared to be in sync, the defense was holding up better and everything seemed to be clicking.Then less than 24 hours after finishing a 41-10 thrashing of the New York Jets , NFL officials made the announcement.The 33-year-old inside linebacker made his only Pro Bowl two years ago and was having another solid season with 81 tackles -- 21 more than anyone else on the roster. He also had one sack and recovered two fumbles.But the more problematic issue is that Jackson was the most experienced inside linebacker on the team and, until Monday night, almost exclusively called the defenses.Edwin Jackson, who had never played in an NFL game until this season, got his first real taste of signal calling in short bursts against the Jets.That was very important because that was my first time actually getting the calls and relaying it to the defense, Edwin Jackson said. You dont want these things to happen, but it happens.The switch may have been coming regardless of the failed drug test.DQwell Jackson left Monday nights game in the fourth quarter with a concussion and had already entered the leagues mandated concussion protocol. Because it usually takes players the better part of a week to clear all the steps, Jacksons status on a short week already could have been in jeopardy for Sundays crucial game with Houston.Losing him for four games, though, will be a bigger blow for a team that hasnt been above .500 all season. Indy still must visit AFC West leader Oakland and playoff contender Minnesota before closing out the season at home against struggling Jacksonville.Coach Chuck Pagano knows it will require more than just good play from Edwin Jackson, an undrafted player who spent last December on Indys practice squad. Theres Morrison, a fourth-round pick out of Florida; Josh McNary, a third-year player from Army who has done most of his work on special teams; and Luke Rhodes, a rookie from William & Mary who was promoted from the practice squad to the active roster Wednesday.Antonios tough, hes smart, he knows the defense inside, out. Hes a downhill, sideline-to-sideline guy. Hell be fine, Pagano said. Hes been told from Day 1 to prepare as a starter for this moment and hes done that. So that will give him a chance to play well.The Colts certainly need Morrison -- and everyone else -- to play well until DQwell Jackson returns.Its the National Football League and youre going to have adversity and youre going to have obstacles, Pagano said. Weve been without our quarterback before. Do you want to be? No. Weve been without (Robert Mathis) before. So its next man up.Game notes Right guard Denzelle Good was diagnosed with a concussion during the Jets game and nose tackle Zach Kerr and outside linebacker Curt Maggitt both complained of concussion-like symptoms after the game. All three are also in the leagues protocol. ... Mathis is listed as day to day with a biceps injury, and safety Clayton Geathers is considered week to week with a neck injury. ... Offensive lineman Joe Reitz, an Indianapolis native, was selected as the teams Walter Payton Man of the Year Award winner.---For more NFL coverage: http://www.pro32.ap.org and http://www.twitter.com/AP-NFL . Mark Gastineau Womens Jersey . Hargreaves began his career in 2008 with the Winnipeg Blue Bombers and has played with the Edmonton Eskimos and last season with the Saskatchewan Roughriders. LaDainian Tomlinson Jets Jersey . - Derek Wolfe says hes finally healthy after suffering a seizure in November that doctors now believe was related to the spinal cord injury he suffered in the preseason. http://www.authenticnyjetspro.com/Trevon-wesco-jets-jersey/ . Defencemen Drew Doughty, Shea Weber and forward Ryan Getzlaf also scored for the Canadians, who started their gold-medal defence 2-0. Goalie Roberto Luongo, getting the call in place of Game 1 starter Carey Price, was solid when needed in making 23 saves for the shutout. Trevon Wesco Jets Jersey . Blackwood, 28, has played the last three seasons in the San Diego Padres system, including the past two summers with Class AA San Antonio of the Texas League. Joe Namath Womens Jersey . Hamelin, who triumphed in the 500 on Saturday, edged out Victor An of Russia by 0.021 seconds to maintain his lead in the World Cup standings. Russias Vladimir Grigorev was third. In the relay, Canada took control six laps from the finish line to beat Russia and the Netherlands. EAST RUTHERFORD, N.J. -- The New York Giants big-bucks, revamped defense found a way to hold off the Dallas Cowboys in the Ben McAdoos debut as coach. Facing the New Orleans Saints on Sunday will show whether spending more than $100 million to help Steve Spagnuolos unit was cost effective.The Giants (1-0) arent going to be facing Dak Prescott, a rookie making his first NFL start.Its Drew Brees this week. The 37-year-old leads the league in passing and comes into the season with 10 consecutive years of passing for more than 4,000 yards, with no less than 4,870 in the last five, which includes three 5,000-yard campaigns.If those numbers dont impress the Giants, all they have to do is recall last year: Brees passed for 511 yards and tied an NFL record with seven touchdown passes in a 52-49 win.I dont even remember that, Giants cornerback Dominique Rodgers-Cromartie quipped.He does, though.When you are playing a guy like that who has been doing it for a long time, you know he has a good arm and has some good receivers who can definitely take the top off a defenses, and you have guys who understand football, and the way he throws and gets it out quick, Rogers-Cromartie said. Man, its going to be tough.Its also going to be tougher for Brees. He will be seeing a lot of new faces.Defensive tackle Damon Harrison and end Olivier Vernon are new, and end Jason Pierre-Paul did not play last year because of his fireworks accident.Middle linebacker Kelvin Sheppard is new, as are cornerbacks Janoris Jenkins and Eli Apple, safeties Darian Thompson and Nat Berhe, who was on injured reserve last year.I would say while its the same scheme for the most part, Steve Spagnuolo, theres a lot of good players over there that seem to be playing really well, Brees said. I dont really look at last year as any type of indication as to how this is going to go. I think theyre much improved. Theyre playing really well right now. I have a lot of respect for coach Spagnuolo and his scheme. Im sure theyre going to be ready for us. We need to make sure were ready for them.New Orleans put up 34 points last week as Brees passed for 423 yards and four touchdowns. The Giants edged Dallas 20-19.SECONDARY CONCERNS: With Delvin Breaux going out for six to eight weeks with a broken leg, the Saints are relying on a trio of cornerbacks with only one regular-season game to their name: starter P.J. Williams and reseerves DeVante Harris and Ken Crawley.dddddddddddd However, a pair of recently acquired veterans could suit up in New York -- Sterling Moore and B.W. Webb, who both practiced this week. Moore knows the Giants well from playing three seasons in the NFC East with the Cowboys (2012-2014). He also played against the Giants last season with Tampa Bay.GIANTS DEFENSIVE BACKS: The Giants limited Prescott to 227 yards passing and no touchdowns. His longest pass was 21 yards.I feel like we have guys that can match up, said Janoris Jenkins, who held Dez Bryant to one catch for 8 yards. We have Eli Apple and DRC. We can match up all the way around the board with anybody as long as we play within the system and play within the scheme.Jenkins said Brees is a `blast from the past, noting he throws deep and works the hash marks most of the time.POUND IT: Running backs Rashad Jennings and Shane Vereen combined for 113 yards on 24 carries in the opener for New York. Expect them to get the ball more after seeing the Saints give up 167 yards on 26 carries in the loss to the Raiders.MORE BREES: Brees looks as good at 37 as he did at 27, if not better. Hes coming off his 14th career 400-yard game, which tied him for first for such single-game production with Peyton Manning in NFL history. His touchdowns included a thread-the-needle throw over the middle to Brandin Cooks, and a Saints-record 98-yarder to Cooks with a pass down the left sideline. That one was so well-timed the speedy receiver never seemed to break stride. With 36 yards passing, Brees will move into third in that category, eclipsing Dan Marinos 61,361 yards.BACK TO NORMAL: Giants receiver Victor Cruz returned in style from a series of injuries, scoring the winning touchdown in his first game since October 2014. This will be his first home game since that season.The only thing that is indicative of things being back to normal is you guys not asking me about my body anymore, Cruz said, and asking me about how I am feeling. But yeah, for the most part it just feels like business as usual, getting out there, playing football again and worrying about our next opponent.---AP Sports Writer Brett Martel in New Orleans contributed to this report.---AP NFL website: www.pro32.ap.org and www.twitter.com/AP-NFL ' ' '